An experience with 5-MeO-DMT is the most intense experience a human can go through, other than their own birth and death. It consistently takes one into the very deepest state of non-ordinary reality. Participants often return with a feeling of a oneness with all and the idea that the feeling of separation from this state is just an illusion; that we are always in a connection to the “source.”
Like its close relatives DMT and bufotenin (5-HO-DMT), it has been used as an entheogen by traditional South American shamans for thousands of years. It is found in some shamanic snuffs and sometimes in ayahuasca brews.
The shaman goes on a “journey” and under goes a transformation that allowed him or her to obtain significant knowledge from direct interaction with the gods.
In modern times, it is consumed in its synthetic powder form for psychospiritual healing, for the pain of separation that can be the underlying desire at the root of all addiction and for end-of-life exploration.
Pharmacology of 5-MeO-DMT
5-MeO-DMT is a naturally occurring psychedelic present in numerous plants and in the venom of the Bufo alvarius toad. It is somewhat comparable in effects to DMT; however it is substantially more potent so great care must be taken and it is highly advisable not to do it alone.
5-MeO-DMT is a methoxylated derivative of DMT. Its pharmacological action is mainly through serotonin receptors. Specifically, it shows high affinity for the 5-HT2 and 5-HT1A subtypes. Additional mechanisms of action such as inhibition of monoamine reuptake may also be involved.